Non‐Directed Cross‐Dehydrogenative (Hetero)arylation of Allylic C(sp³)−H bonds enabled by C−H Activation

Abstract

Herein, we report the selective, non-directed and cross-dehydrogenative coupling of allylic C(sp³ )-H bonds with C(sp² )-H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late-stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C-C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.