Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status

Abstract

Quercetin is more efficacious for improving cognitive function under low vitamin D status. This might be owing to that interventions reduce Aβ plaques, tau phosphorylation, and neuroinflammation, upregulate BDNF, reduce miR-26a and miR-125b, increase miR-132, and elevate gut microbial diversity including Facklamia and Aerococcus.