Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

Autophagy regulates lipid metabolism

Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature · 2009 · 3.8K citations · Full text

Cell Autophagy, Mitophagy, Lipid Metabolism +7

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Kurt Degenhardt, Robin Mathew, Brian Beaudoin et al. · Cancer Cell · 2006 · 2K citations · Full text

Inflammation, Cell Autophagy, Tumor Cell Survival +11

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

Jiali Yang, Cuicui Pi, Guanghui Wang · Biomedicine & Pharmacotherapy · 2018 · 424 citations

Cell Autophagy, Mitophagy, Signaling Pathway +12

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

Shinji Saiki, Yukiko Sasazawa, Yoko Imamichi et al. · Autophagy · 2011 · 417 citations · Full text

Cell Autophagy, Mitophagy, Signal Transduction +15

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

Barry Fine, Cindy Hodakoski, Susan Koujak et al. · Science · 2009 · 242 citations · Full text

Tumor Biology, Signal Transduction, Signaling Pathway +14