Concepedia

Inhibition of Protein Phosphatase 2A Sensitizes Mucoepidermoid Carcinoma to Chemotherapy via the PI3K-AKT Pathway in Response to Insulin Stimulus

Limin Liu, Herui Wang, Jing Cui, Qi Zhang, Wei Zhang, Wanlin Xu, Hao Lü, Shengwen Liu, Shukun Shen, Francia Fang,

Cellular Physiology and Biochemistry · 2018 · 19 citations · 36 references

Open access

Abstract

These results highlight the translational potential of PP2A inhibition to synergize with cisplatin in mucoepidermoid carcinoma treatment.

References

36

Mucoepidermoid Carcinoma

Margaret Brandwein, Katya Ivanov, Derrick I. Wallace et al. · The American Journal of Surgical Pathology · 2001 · 535 citations

Afip Grading, Cancer Detection, Medicine +8

The role of radiotherapy in the treatment of malignant salivary gland tumors

Chris H.J. Terhaard, Herman Lubsen, C. Rasch et al. · International Journal of Radiation Oncology*Biology*Physics · 2004 · 405 citations

Radiation Therapy, Medicine, Head And Neck Cancer +6

Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action

Isabelle Mothe‐Satney, Emmanuel Van Obberghen · Journal of Biological Chemistry · 1996 · 254 citations · Full text

Insulin Receptor, Insulin Signaling, Modulates Insulin Action +20

Phosphatase PP2A is requisite for the function of regulatory T cells

Sokratis A. Apostolidis, Noé Rodríguez‐Rodríguez, Abel Suárez‐Fueyo et al. · Nature Immunology · 2016 · 241 citations · Full text

Signal Transduction, Signaling Pathway, Natural Sciences +12

Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes

Satoshi Ugi, Takeshi Imamura, Hiroshi Maegawa et al. · Molecular and Cellular Biology · 2004 · 236 citations · Full text