Concepedia

Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine

Michelle Z. Dion, Danielle L. Leiske, Vikas Sharma, Christina L. Zuch de Zafra, Cleo M. Salisbury

Pharmaceutical Research · 2018 · 39 citations · 39 references

DOI

Concepts

References

39

THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULE

Gerald M. Edelman, Bruce A. Cunningham, W. Einar Gall et al. · Proceedings of the National Academy of Sciences · 1969 · 895 citations · Full text

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The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics

Ravuri S. K. Kishore, Sylvia Kiese, Stefan Fischer et al. · Pharmaceutical Research · 2011 · 300 citations

, , +14

Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

Shihong Li, Christian Schöneich, Ronald T. Borchardt · Biotechnology and Bioengineering · 1995 · 297 citations

, , +15

Antioxidants for Prevention of Methionine Oxidation in Recombinant Monoclonal Antibody HER2

Xanthe M. Lam, Janet Yang, Jeffrey L. Cleland · Journal of Pharmaceutical Sciences · 1997 · 265 citations

, , +14

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

Dingjiang Liu, Da Ren, Holly S. Huang et al. · Biochemistry · 2008 · 262 citations

, , +13