Organocatalytic enantioselective Mannich-type addition of 5<i>H</i>-thiazol-4-ones to isatin-derived imines: access to 3-substituted 3-amino-2-oxindoles featured by vicinal sulfur-containing tetrasubstituted stereocenters

Abstract

3-Substituted 3-amino-2-oxindoles featuring both 5<italic>H</italic>-thiazol-4-one and vicinal sulfur-containing tetrasubstituted stereocenter structural motifs were obtained in high yields with excellent enantioselectivities and diastereoselectivities.