Investigating the Antiproliferative and Antioxidant Properties of <i>Pancratium maritimum</i> L. (Amaryllidaceae) Stems, Flowers, Bulbs, and Fruits Extracts

Abstract

<i>Pancratium maritimum</i> stems, flowers, bulbs, and fruits extracts were investigated for their antiproliferative and antioxidant properties. Total phenols and total flavonoids were also determined. The <i>in vitro</i> antiproliferative activity was tested against seven cancer cell lines such as C32, HeLa, MDA-MB-231, PC3, A549, MCF-7, and LNCaP by using SRB assay. Interesting results were obtained with stems ethanol extract (ET1) against C32 cells (IC₅₀ of 27.1 <i>μ</i>g/mL) and fruits aqueous extract (AQ) against MCF-7 cell line (IC₅₀ of 36.5 <i>μ</i>g/mL). To define the antioxidant activity, four tests such as DPPH, ABTS FRAP, and <i>β</i>-carotene bleaching tests were used. The most promising ABTS scavenging capacity was observed with fruits ethanol extract (ET1) that showed an IC₅₀ value of 6.9 <i>μ</i>g/mL. According to the correlation results, the phenols and flavonoids content could provide a fundamental contribution to the antioxidant and antiproliferative activity of <i>P. maritimum</i> extracts.