Gender Differences in Global Functional Connectivity During Facial Emotion Processing: A Visual MMN Study

Abstract

To investigate gender differences in functional connectivity during the unattended processing of facial expressions, we recorded visual mismatch negativity (vMMN) in 34 adults using a deviant-standard reverse oddball paradigm. Using wavelet analysis, we calculated the time-frequency (TF) power at each electrode associated with happy-deviant, sad-deviant, happy-standard and sad-standard conditions. We also calculated the phase lag index (PLI) between electrode pairs and analyzed the dynamic network topologies of the functional connectivity for happy and sad vMMNs in the delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz) and gamma (30-45 Hz) bands. The results showed that females induced stronger TF power and PLI values than males in only the alpha band over the whole brain regarding the vMMN. Moreover, females had a higher ratio of the number of connections between long-distance electrode pairs than males. While theoretical analysis of dynamic network topologies indicated that high node degree values were found in local brain regions of males and in almost the entire female brain, our findings suggested that female brain activation and connections between brain regions are not only stronger but also more widely distributed during the unattended processing of facial expressions than those in males.