Gain-of-Function Mutation in Filamin A Potentiates Platelet Integrin α _IIb β ₃ Activation

Abstract

Altogether, our results are consistent with a less binding of mutant FLNa to β₃ and the facilitated recruitment of talin by β₃ on platelet stimulation, explaining the increased α_IIbβ₃ activation and the ensuing gain-of-platelet functions.