N‐Heterocyclic Carbene‐Catalyzed <i>in situ</i> Activation of Alkynyl Acids for C−S Bond Formation: Access to Imidazo[2,1‐<i>b</i>][1,3]thiazinones

Abstract

Abstract Alkynyl acids are first utilized as alkynyl acylazolium precursors through an in situ activation strategy for the efficient construction of carbon‐sulfur bond in a formal [3+3] annulation. This protocol offers a direct and rapid pathway for the synthesis of imidazo[2,1‐ b ][1,3]thiazinone skeleton, a useful heterocyclic class frequently found in many bioactive compounds. This reaction also has the advantages of scalability, readily available materials, and simple manipulation in open air. magnified image