Immunogenicity to cerliponase alfa intracerebroventricular enzyme replacement therapy for CLN2 disease: Results from a Phase 1/2 study

Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid Lipofuscinosis

David E. Sleat, Robert Donnelly, Henry Lackland et al. · Science · 1997 · 583 citations

Life Sciences, Genetics, Neuroscience +15

Study of Intraventricular Cerliponase Alfa for CLN2 Disease

Angela Schulz, Temitayo Ajayi, Nicola Specchio et al. · New England Journal of Medicine · 2018 · 483 citations

Life Sciences, Neurology, Neuroscience +9

Immunogenicity of protein therapeutics: The key causes, consequences and challenges

Matthew Baker, Helen Reynolds, Brooke Lumicisi et al. · Self/Nonself · 2010 · 363 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Adverse drug reactions: types and treatment options.

Marc A. Riedl, Adrian Casillas · PubMed · 2003 · 275 citations

Life Sciences, Immunology, Pharmacology +11

Mutational Analysis of the Defective Protease in Classic Late-Infantile Neuronal Ceroid Lipofuscinosis, a Neurodegenerative Lysosomal Storage Disorder

David E. Sleat, Rosalie M. Gin, István Sohár et al. · The American Journal of Human Genetics · 1999 · 180 citations · Full text

Life Sciences, Genetics, Neuroscience +16