Concepedia

Metformin Protects against H2O2-Induced Cardiomyocyte Injury by Inhibiting the miR-1a-3p/GRP94 Pathway

Ying Zhang, Xue Liu, Lu Zhang, Xuelian Li, Zhongqiu Zhou, Lei Jiao, Yingchun Shao, Mengmeng Li, Bing Leng, Yuhong Zhou,

Molecular Therapy — Nucleic Acids · 2018 · 102 citations · 25 references

DOIFull text

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Concepts

Abstract

damage through the AMPK/C/EBP β/miR-1a-3p/GRP94 pathway, which indicates that metformin may be applied for the treatment of I/R injury.

References

25

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

Baofeng Yang, Huixian Lin, Jiening Xiao et al. · Nature Medicine · 2007 · 1.1K citations

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Myogenic factors that regulate expression of muscle-specific microRNAs

Prakash K. Rao, Roshan Kumar, Mina Farkhondeh et al. · Proceedings of the National Academy of Sciences · 2006 · 691 citations · Full text

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MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial Fibrillation

Yanjie Lu, Ying Zhang, Ning Wang et al. · Circulation · 2010 · 443 citations · Full text

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Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

Susheel Gundewar, John W. Calvert, Saurabh Kumar Jha et al. · Circulation Research · 2008 · 416 citations · Full text

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