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Follicular helper T cells promote the effector functions of CD8+ T cells via the provision of IL-21, which is downregulated due to PD-1/PD-L1-mediated suppression in colorectal cancer

Pd-1/pd-l1-mediated SuppressionCancer ImmunosurveillanceAutoimmune DiseaseT-regulatory CellImmunologyColorectal CancerAutoimmunityCd8+ T CellsImmunotherapyMedicineCell BiologyTumor Microenvironment