Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions—Brief Report

Abstract

Mimicking age-related modulation of laminin β1 versus β2 chain expression changes the functional properties and phenotype of endothelial cells. The dysregulation of the extracellular matrix during vascular aging may contribute to age-associated impairment of organ function and fibrosis.