Concepedia

Ultrasound Microbubble Delivery Targeting Intraplaque Neovascularization Inhibits Atherosclerotic Plaque in an APOE-deficient Mouse Model

Hong Yuan, Haiqiang Hu, Jindong Sun, Shi Mingjuan, Huamin Yu, Cairong Li, YU SUN, Zhijian Yang, Robert M. Hoffman

In Vivo · 2018 · 25 citations · 22 references

DOIFull text

Open access

Abstract

UTMD targeting intraplaque neovascularization was found to inhibit atherosclerotic plaque in a mouse model of atherosclerosis, suggesting the potential of microbubble-mediated ultrasound technology in aiding drug delivery for atherosclerosis treatment.

References

22

Intraplaque Hemorrhage and Progression of Coronary Atheroma

Frank D. Kolodgie, Herman K. Gold, Allen Burke et al. · New England Journal of Medicine · 2003 · 1.5K citations · Full text

Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta

Pedro Moreno, K‐Raman Purushothaman, Valentı́n Fuster et al. · Circulation · 2004 · 620 citations · Full text

Arterial Neovascularization and Inflammation in Vulnerable Patients

Michael Fleiner, Marco Kummer, Martina Mirlacher et al. · Circulation · 2004 · 347 citations · Full text

Ultrasound-Targeted Microbubble Destruction Can Repeatedly Direct Highly Specific Plasmid Expression to the Heart

Raffi Bekeredjian, Shuyuan Chen, Peter Frenkel et al. · Circulation · 2003 · 319 citations · Full text

Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells

Yun Ling, Yong Yang, Na Lu et al. · Biochemical and Biophysical Research Communications · 2007 · 249 citations

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