Chemical Communications · 2018 · 52 citations · 26 references
Life SciencesCell BiologyMolecular BiologyRna BiologyStructural BiologyTranscriptional RegulationG-quadruplex ChemistryMicrorna BiogenesisMicrorna BiologyMicrorna-mediated RegulationRna StructureRna-protein InteractionsG-quadruplex Loop StructuresG-quadruplex RepeatsMicrorna Precursor StructurePost-transcriptional Gene RegulationPost-transcriptional RegulationPost-transcriptional Regulation Of Microrna Biogenesis
Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.
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Prevalence of quadruplexes in the human genome
J Huppert, Shankar Balasubramanian · Nucleic Acids Research · 2005 · 1.7K citations · Full text
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Sunita Kumari, Anthony Bugaut, J Huppert et al. · Nature Chemical Biology · 2007 · 822 citations · Full text