Revista Española de Enfermedades Digestivas · 2018 · 18 citations · 0 references
Life SciencesGeneticsImmunologyAutoimmunityHuman GeneticsImmunogeneticsAutoimmune Disease PathogenesisAutoimmune Disease Susceptibility GenesAutoimmune DiseasesCeliac DiseaseGenetic Susceptibility To AutoimmunityMajor Histocompatibility ComplexAutoimmune EnteropathyCeliac Disease ImmunogeneticsCeliac Disease ImmunologyCeliac Disease PathogenesisHla Autoimmune Disease AssociationsHla ImmunogeneticsHla Risk AllelesHla-dq2 Genetics
Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry.