<i>APOE</i> ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

Abstract

Our results indicate that <i>APOE</i> ε4 is independently associated with a greater severity of LB pathology. These findings increase our understanding of the mechanism behind reported associations of ε4 with risk of dementia with Lewy bodies and Parkinson disease with dementia, and suggest that ε4 may function as a modifier of processes that favor LB spread rather than acting directly to initiate LB pathology.