Functional <i>Ex Vivo</i> Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects

Abstract

RECAP is a robust functional HR assay detecting both <i>BRCA1/2</i>-deficient and <i>BRCA1/2</i>-proficient HRD tumors. Functional assessment of HR in a pseudo-diagnostic setting is achievable and produces robust and interpretable results.