Magnetite Nanocontainers: Toward Injectable Highly Magnetic Materials for Targeted Drug Delivery

Abstract

Nanocontainers based solely on magnetite NPs have been synthesized by indirect gelation of stable magnetite hydrosol at ambient temperature using the microemulsion-assisted sol-gel method. Containers synthesized have adjustable size and consist of ∼10 nm magnetite nanoparticles linked by Fe-O-Fe interparticle bonds. The material demonstrates high magnetization values up to 60 emu/g and low cytotoxicity against both HeLa and postnatal human fibroblast (up to 260 μg/mL). The systems developed are perspective as a drug depot, particularly for magnetically controlled thrombolysis.