Concepedia

AKR1C3, a crucial androgenic enzyme in prostate cancer, promotes epithelial-mesenchymal transition and metastasis through activating ERK signaling

Bin Wang, Yanan Gu, Ke Hui, Jun Huang, Shan Xu, Shiqi Wu, Lei Li, Jinhai Fan, Xinyang Wang, Jer‐Tsong Hsieh,

Urologic Oncology Seminars and Original Investigations · 2018 · 55 citations · 18 references

DOI

Concepts

References

18

Cancer statistics, 2016

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2016 · 16.2K citations · Full text

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Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer

Michael Stanbrough, Glenn J. Bubley, Kenneth N. Ross et al. · Cancer Research · 2006 · 1.1K citations · Full text

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Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells

Yan Gan, Chengjian Shi, Landon J. Inge et al. · Oncogene · 2010 · 269 citations

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Intracrine Androgens and AKR1C3 Activation Confer Resistance to Enzalutamide in Prostate Cancer

Chengfei Liu, Wei Lou, Yezi Zhu et al. · Cancer Research · 2015 · 242 citations · Full text

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Steroidogenic Enzyme AKR1C3 Is a Novel Androgen Receptor-Selective Coactivator that Promotes Prostate Cancer Growth

Muralimohan Yepuru, Zhongzhi Wu, Anand Kulkarni et al. · Clinical Cancer Research · 2013 · 120 citations

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