Terezine E, bioactive prenylated tryptophan analogue from an endophyte of<i>Centaurea stoebe</i>

Abstract

Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a <i>Mucor</i> sp. has been isolated as an endophyte from the medicinal plant <i>Centaurea stoebe</i>. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.