First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America

Abstract

One of the most recently described <i>Aspergillus fumigatus</i><i>CYP51A</i>-mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical <i>A. fumigatus</i> strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical <i>A. fumigatus</i> strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.