Trametinib for progressive pediatric low-grade gliomas

Tandem Duplication Producing a Novel Oncogenic <i>BRAF</i> Fusion Gene Defines the Majority of Pilocytic Astrocytomas

David Jones, Sylvia Kocialkowski, Lu Liu et al. · Cancer Research · 2008 · 942 citations · Full text

Medicine, Genetics, Oncology +17

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

David Jones, Barbara Hutter, Natalie Jäger et al. · Nature Genetics · 2013 · 835 citations · Full text

Medicine, Oncology, Pathology +10

Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas

Eva Dombi, Andrea Baldwin, Leigh Marcus et al. · New England Journal of Medicine · 2016 · 665 citations · Full text

Medicine, Neurology, Oncology +16

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

Stefan M. Pfister, Wibke G. Janzarik, Marc Remke et al. · Journal of Clinical Investigation · 2008 · 517 citations · Full text

Medicine, Genetics, Oncology +17

Phase II Study of the MEK1/MEK2 Inhibitor Trametinib in Patients With Metastatic <i>BRAF</i> -Mutant Cutaneous Melanoma Previously Treated With or Without a BRAF Inhibitor

Kevin B. Kim, Richard Kefford, Anna C. Pavlick et al. · Journal of Clinical Oncology · 2012 · 477 citations · Full text

Medicine, Oncology, Pharmacology +17