Concepedia

Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-β1 pathway

Xiaohe Li, Cheng Lu, Shuangwei Liu, Shuaishuai Liu, Chengcheng Su, Ting Xiao, Zhun Bi, Pengzhen Sheng, Mengying Huang, Xinhua Liu,

European Journal of Medicinal Chemistry · 2018 · 26 citations · 20 references

DOI

Concepts

References

20

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Patricia J. Sime, Frank L. Graham, Karl G. Csaky et al. · Journal of Clinical Investigation · 1997 · 1K citations · Full text

, , +17

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

Jingsong Zhao, Wei Shi, Yanling Wang et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2002 · 411 citations

, , +17

Regulation of pulmonary fibrosis by chemokine receptor CXCR3

Dianhua Jiang, Jiurong Liang, Jennifer Hodge et al. · Journal of Clinical Investigation · 2004 · 304 citations · Full text

, , +15

Progressive Transforming Growth Factor β1–induced Lung Fibrosis Is Blocked by an Orally Active ALK5 Kinase Inhibitor

Philippe Bonniaud, Peter J. Margetts, Martin Kolb et al. · American Journal of Respiratory and Critical Care Medicine · 2004 · 252 citations

, , +17

Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis.

Robina K Coker, Shahriar Shahzeidi, Penny Lympany et al. · PubMed · 1997 · 248 citations

, , +15