Synthesis of pyrazolo-1,2,4-triazolo[4,3- <i>a</i> ]quinoxalines as Antimicrobial Agents with Potential Inhibition of DHPS Enzyme

Abstract

Compounds 5b, 5c were equipotent (minimal inhibitory concentration = 12.5 μg/ml) to ampicillin. The docking patterns of 5b and 5c demonstrated that both fit into Bacillus Anthracis dihydropteroate synthase pterin and p-amino benzoic acid-binding pockets. Moreover, their physicochemical properties and pharmacokinetic profiles recommend that they can be considered drug-like candidates. The results highlight some significant information for the future design of lead compounds as antimicrobial agents.