Tetrahedral <scp>DNA</scp> nanostructures facilitate neural stem cell migration <i>via</i> activating <scp>RHOA</scp>/<scp>ROCK</scp>2 signalling pathway

Abstract

In conclusion, TDNs could enter NSCs without the aid of other transfection reagents in large amounts, whereas only small amounts of ssDNA could enter the cells. TDNs taken up by NSCs activated the RHOA/ROCK2 signalling pathway, which had effects on the relevant genes and proteins expression, eventually promoting the migration of NE-4C stem cells. These findings suggested that TDNs have great potential in application for the repair and regeneration of neural tissue.