Acetaminophen, ibuprofen, and tramadol analgesic interactions after adenotonsillectomy

Abstract

Ibuprofen has an EC₅₀ for analgesia in children similar to that of adults (3.95 mg/L; 95%CI 2.57-7.53, vs 5-10 mg/L adults). The maximum effect from combination therapy (ie, 65% reduction in pain score) achieves satisfactory analgesia with commonly used doses but increased dose adds little additional benefit. The addition of tramadol to this analgesic mixture prolongs analgesia duration.