Histogram Analysis of Perfusion Parameters from Dynamic Contrast-Enhanced MR Imaging with Tumor Characteristics and Therapeutic Response in Locally Advanced Rectal Cancer

Abstract

These preliminary results suggest that a larger proportion of higher AUC skewness was present in LN metastasis group and a higher v_p histogram value was present in rectal cancer with PNI. In addition, K^trans and k_ep histogram parameters showed difference according to the KRAS mutation, demonstrating the utility of the histogram of perfusion parameters derived from DCE-MRI as potential imaging biomarkers of tumor characteristics and genetic features.