Concepedia

Publication | Closed Access

Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma

DOI

91

Citations

39

References

2018

Year

Nur P. Damayanti, Justin A. Budka, Heba Khella, Mary W. Ferris, Sheng‐Yu Ku, Eric Kauffman, Anthony C. Wood, Khunsha Ahmed, Venkata Nithinsai Chintala, Remi Adelaiye‐Ogala,
Clinical Cancer Research

Abstract

These results identify TFE3/IRS-1/PI3K/AKT/mTOR as a potential dysregulated pathway in TFE3-tRCC, and suggest a therapeutic potential of vertical inhibition of this axis by using a dual PI3K/mTOR inhibitor for patients with TFE3-tRCC.

References

YearCitations

Page 1