Polymorphic 2-hydroxylation of desipramine

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

David A. Evans, A. Mahgoub, T.P. Sloan et al. · Journal of Medical Genetics · 1980 · 540 citations · Full text

Life Sciences, Genetics, Pharmacology +17

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

Markus H. Heim, Urs Meyer · The Lancet · 1990 · 451 citations

Life Sciences, Genetics, Molecular Genetics +7

Complex Segregation Analysis with Pointers

Jean-Marc Lalouel, N.E. Morton · Human Heredity · 1981 · 377 citations

Life Sciences, Genetics, Human Genetics +13

Skewness in Commingled Distributions

C J MacLean, Newton E. Morton, Robert C. Elston et al. · Biometrics · 1976 · 329 citations

Natural Sciences, Biostatistics, Evolutionary Biology +13

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

Masaaki Kagimoto, Markus H. Heim, Keiko Kagimoto et al. · Journal of Biological Chemistry · 1990 · 267 citations · Full text

Medicine, Genetics, Pharmacology +17