Concepedia

Oxa/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells

Guillermo Valdomir, María de los Ángeles Fernández, Irene Lagunes, Juan I. Padrón, Juan I. Padrón, Victor S. Martı́n, Danilo Davyt

New Journal of Chemistry · 2018 · 28 citations · 32 references

DOI

Concepts

Abstract

Inspired by marine bioactive compounds, the principle of molecular hybridization was applied combining diverse heterocyclic systems by a triazole ring, to produce new and more active compounds.

References

32

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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Phorboxazoles A and B: potent cytostatic macrolides from marine sponge Phorbas species

Philip A. Searle, Tadeusz F. Molinski · Journal of the American Chemical Society · 1995 · 287 citations

, , +14

A New Catalytic Prins Cyclization Leading to Oxa- and Azacycles

Pedro O. Miranda, Rubén M. Carballo, Victor S. Martı́n et al. · Organic Letters · 2008 · 125 citations

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Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine Sponge <i>Cinachyrella enigmatica</i>

Naoya Oku, Kentaro Takada, Richard W. Fuller et al. · Journal of the American Chemical Society · 2010 · 91 citations · Full text

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Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity

Alessandra Bisi, Concettina Cappadone, Angela Rampa et al. · European Journal of Medicinal Chemistry · 2017 · 82 citations · Full text

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