Interleukin 17 under hypoxia mimetic condition augments osteoclast mediated bone erosion and expression of HIF-1α and MMP-9

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation · 1999 · 1.7K citations · Full text

Medicine, Cell Biology, Immunology +17

IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

Susumu Nakae, Shinobu Saijo, Reiko Horai et al. · Proceedings of the National Academy of Sciences · 2003 · 484 citations

Medicine, Immunology, Pathology +15

Hypoxia is a major stimulator of osteoclast formation and bone resorption

Timothy R. Arnett, Daniel C. Gibbons, Jennifer C. Utting et al. · Journal of Cellular Physiology · 2003 · 322 citations · Full text

Medicine, Cell Biology, Physiology +17

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

Iannis E. Adamopoulos, Cheng‐Chi Chao, Richard Geissler et al. · Arthritis Research & Therapy · 2010 · 296 citations · Full text

Medicine, Immunology, Pathobiology +17

CONTRIBUTION OF INTERLEUKIN 17 TO SYNOVIUM MATRIX DESTRUCTION IN RHEUMATOID ARTHRITIS

Martine Chabaud, Patrick Garnero, Jean‐Michel Dayer et al. · Cytokine · 2000 · 277 citations

Medicine, Immunology, Orthopaedic Surgery +12