TRPV1 and TRPM8 Channels and Nocifensive Behavior in a Rat Model for Dry Eye

Abstract

These results suggest that TRPV1 plays a significant role in mediating enhanced nocifensive behavior in DE, while TRPM8 may play a lesser role. Strategies to target specific transducer molecules on corneal nerves may prove beneficial as adjunct therapies in managing ocular pain in moderate to severe cases of DE.