Chemical Communications · 2018 · 115 citations · 26 references
Natural SciencesChemistryPharmacologyBiomedical OpticsBiophotonicsBiophysical ChemistryFluorescence SpectroscopyPhotochemical KineticsPhotochemistryPhotodynamic TherapyPhotophysics Of Fluorescent ProbesCancer Photodynamic TherapyPhotophysical MechanismsPhotosensitizersPhotosensitizing CompoundsSinglet Oxygen GenerationSinglet Oxygen QuenchingTriplet State ChemistryTriplet State Lifetimes
A water-soluble near-infrared aminocyanine dye has been developed with a long triplet-state lifetime (τ = 9.16 μs in deaerated ethanol). Thereby, extremely high singlet oxygen quantum yield (ΦΔ = 0.20) and low dark cytotoxicity (IC50 = 715.4 μM) were achieved. The potential of the dye as a PDT photosensitizer was demonstrated.
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