Metformin use and incidence cancer risk: evidence for a selective protective effect against liver cancer

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

Life Sciences, Biochemistry, Endocrinology +17

Evaluating Medication Effects Outside of Clinical Trials: New-User Designs

Wayne A. Ray · American Journal of Epidemiology · 2003 · 1.6K citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +12

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Hannah R. Bridges, Andrew J. Y. Jones, Michaël Pollak et al. · Biochemical Journal · 2014 · 655 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Comparative Effectiveness of Sulfonylurea and Metformin Monotherapy on Cardiovascular Events in Type 2 Diabetes Mellitus

Christianne L. Roumie, Adriana M. Hung, Robert A. Greevy et al. · Annals of Internal Medicine · 2012 · 299 citations

Pharmacy, Internal Medicine, Pharmacotherapy +14

Metformin Does Not Affect Cancer Risk: A Cohort Study in the U.K. Clinical Practice Research Datalink Analyzed Like an Intention-to-Treat Trial

Konstantinos K. Tsilidis, Despoina Capothanassi, Naomi E. Allen et al. · Diabetes Care · 2014 · 183 citations

Medicine, Oncology, Pharmacotherapy +10