Hannah R. Bridges

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Hannah R. Bridges, Andrew J. Y. Jones, Michaël Pollak et al. · Biochemical Journal · 2014 · 633 citations · Full text

Biguanide Metformin, Systems Biology, Mitochondrial Function +13

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

Ahmed-Noor A. Agip, James N. Blaza, Hannah R. Bridges et al. · Nature Structural & Molecular Biology · 2018 · 237 citations · Full text

Mitochondrial Biogenesis, Mitochondrial Function, Organelle Dynamic +13

Structural basis for a complex I mutation that blocks pathological ROS production

Zhan Yin, Nils Burger, Duvaraka Kula‐Alwar et al. · Nature Communications · 2021 · 121 citations · Full text

Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides

Hannah R. Bridges, James N. Blaza, Zhan Yin et al. · Science · 2023 · 118 citations · Full text

Structure of inhibitor-bound mammalian complex I

Hannah R. Bridges, Justin G. Fedor, James N. Blaza et al. · Nature Communications · 2020 · 99 citations · Full text