Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

Jillian M. Richmond, James P. Strassner, Lucio Zapata, Madhuri Garg, Rebecca L. Riding, Maggi Ahmed Refat, Xueli Fan, Vincent Azzolino, Andrea Tovar‐Garza, Naoya Tsurushita,

Science Translational Medicine · 2018 · 270 citations · 39 references

Concepts

Abstract

Human and mouse resident memory T cells are present in vitiligo lesions, and blocking IL-15 signaling provides long-lasting reversal of disease in a mouse model of vitiligo.

References

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