Concepedia

Pd(0)/PR<sub>3</sub>-Catalyzed Intermolecular Arylation of sp<sup>3</sup> C−H Bonds

Masayuki Wasa, Keary M. Engle, Jin‐Quan Yu

Journal of the American Chemical Society · 2009 · 313 citations · 22 references

DOI

Concepts

Abstract

Pd(0)-catalyzed intermolecular arylation of sp(3) C-H bonds has been achieved using PR(3)/ArI. This protocol can be used to arylate a variety of aliphatic carboxylic acid derivatives, including a number of bioactive drug molecules. The use of fluorinated aryl iodides also allows for the introduction of fluorine into a molecule of interest.

References

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