Chronic clozapine treatment restrains via HDAC2 the performance of mGlu2 receptor agonism in a rodent model of antipsychotic activity

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

Jeffrey A. Lieberman, T. Scott Stroup, Joseph P. McEvoy et al. · New England Journal of Medicine · 2005 · 5.9K citations · Full text

Medicine, Pharmacotherapy, Psychiatry +14

HDAC2 negatively regulates memory formation and synaptic plasticity

Ji‐Song Guan, Stephen J. Haggarty, Emanuela Giacometti et al. · Nature · 2009 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +14

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Sandeep T. Patil, Lu Zhang, Ferenc Martényi et al. · Nature Medicine · 2007 · 1K citations

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Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

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Life Sciences, Neuroscience, Pharmacology +9

An epigenetic blockade of cognitive functions in the neurodegenerating brain

Johannes Gräff, Damien Rei, Ji‐Song Guan et al. · Nature · 2012 · 852 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16