Concepedia

Leptin administration alleviates ischemic brain injury in mice by reducing oxidative stress and subsequent neuronal apoptosis

Jinying Zhang, Yiling Si, Jie Liao, Guang‐Tao Yan, Zihui Deng, Hui Xue, Lu-Huan Wang, Kai Zhang

The Journal of Trauma: Injury, Infection, and Critical Care · 2012 · 31 citations · 19 references

Abstract

Peripherally administered leptin crossed the blood-brain barrier and was distributed into multiple regions of the brain; in the brain, leptin directly alleviated the injury-evoked damages by reducing oxidative stress and neuronal apoptosis.

References

19

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.4K citations · Full text

Mca Occlusion, Cerebral Vascular Regulation, Neurovascular Disease +18

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.2K citations · Full text

Protein Function, Signal Transduction, Biochemistry +12

Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

Tomomi Kuwana, Mason Mackey, Guy Perkins et al. · Cell · 2002 · 1.5K citations · Full text

Proteinlipid Interaction, Biochemistry, Natural Sciences +7

Leptin enters the brain by a saturable system independent of insulin

William A. Banks, Abba J. Kastin, Wei Tao Huang et al. · Peptides · 1996 · 1.2K citations

Insulin Signaling, Neuropeptides, Neurophysiology +11