Infection and Immunity · 2018 · 51 citations · 77 references
Life SciencesMicrobiologyMolecular BiologyHost-pathogen InteractionsInnate ImmunityProtein TranslationParasitic Disease PathogenesisParasitic PathogenesisProtozoal InfectionsProtozoan Host-parasite InteractionsProtozoan ImmunologyProtozoan PathogenesisHost Cell ModulationHost Immune Response ModulationLocalized Mrna TranslationMrna Translation EfficiencyMrna Translation InitiationMrna Translation TerminationProtozoan Immune ModulationToxoplasmosis Pathogenesis
The intracellular parasite Toxoplasma gondii promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II T. gondii strains causes a profound perturbation of the host cell translatome.
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Fiji: an open-source platform for biological-image analysis
Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods · 2012 · 70.9K citations
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations