Metal-Free Electrophilic Trifluoroethylthiolation with NaSO₂CH₂CF₃

Abstract

Metal-free trifluoroethylthiolation with fluorinated sulfinate salt NaSO₂CH₂CF₃ under reductive conditions has been developed. The strategy enables the installation of the SCH₂CF₃ moiety efficiently to form a number of unexplored stable trifluoroethylthiolated heterocycles, arenes, and thiols, which have the potential to be a new series of fluorine-containing chemical entities for medicinal chemists.