Concepedia

Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation

Weiqiang Jia, Zhaotao Wang, Mingming Zou, Jianhao Lin, Yehai Li, Liang Zhang, Ruxiang Xu

Cellular Physiology and Biochemistry · 2018 · 50 citations · 27 references

DOIFull text

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Abstract

This study demonstrates that VB inhibits glioblastoma cell proliferation, migration, and invasion while promoting apoptosis via SHP-1 activation and inhibition of STAT3 phosphorylation.

References

27

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010

Quinn T. Ostrom, Haley Gittleman, P Farah et al. · Neuro-Oncology · 2013 · 12.1K citations · Full text

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

Brenda Auffinger, Alex L. Tobias, Yu Han et al. · Cell Death and Differentiation · 2014 · 333 citations · Full text

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Temozolomide Preferentially Depletes Cancer Stem Cells in Glioblastoma

Dagmar Beier, Stefanie Röhrl, Deepu R. Pillai et al. · Cancer Research · 2008 · 289 citations

Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma

Alba A. Brandes, Enrico Franceschi, Alicia Tosoni et al. · Cancer · 2009 · 220 citations

Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

Yajun Han, Hesham M. Amin, Bevin Franko et al. · Blood · 2006 · 175 citations