Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck, Leila Akkari, Alberto J. Schuhmacher et al. · Nature Medicine · 2013 · 2.5K citations · Full text

Life Sciences, Neuroscience, Oncology +12

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

Monica R. P. Elmore, Allison R. Najafi, Maya A. Koike et al. · Neuron · 2014 · 2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

David G. DeNardo, Donal J. Brennan, Elton Rexhepaj et al. · Cancer Discovery · 2011 · 1.7K citations

Medicine, Immunology, Oncology +17

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

William D. Tap, Zev A. Wainberg, Stephen P. Anthony et al. · New England Journal of Medicine · 2015 · 582 citations

Medicine, Oncology, Pharmacology +15

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

Nicholas Butowski, Howard Colman, John de Groot et al. · Neuro-Oncology · 2015 · 580 citations · Full text

Medicine, Oncology, Pharmacology +17