Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole‐Linked Chalcone Derivatives

Abstract

Abstract In the current study, an efficient synthesis of new triazole‐linked chalcone 3 a‐g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa , Escherchia coli , Staphylococcus aureus and Bacillus subtilis . The preliminary result revealed that 3 f exhibited a promising antibacterial activity. Furthermore, 3 f was modified at α, β‐ unsaturated carbonyl segment to isoxazoline 4 a , pyrimidines 5 a , 6 a‐b , pyrazoles 7 a‐c and cyanopyridine 8 a . Within the modified compounds 7 b (4‐nitro‐substituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5 a and 8 a showed promising free radical scavenging activity.