Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs - Concepedia

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Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

DOI Full Paper Access

54

Citations

22

References

2018

Year

Adaobi Okonkwo, Joy Mitra, Gavin S. Johnson, Li Li, Wan Mohaiza Dashwood, Muralidhar L. Hegde, Yue Chen, Roderick H. Dashwood, Praveen Rajendran

Molecular Nutrition & Food Research

Abstract

Novel tetrazole-containing heterocyclic analogs of SFN provide a new avenue for chemosensitization in colon cancer cells via modulation of HAT/HDAC activities and associated DNA damage/repair signaling pathways.

References

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