Inference of Crosstalk Effects between DNA Methylation and lncRNA Regulation in NSCLC

Abstract

Intercellular crosstalk effects between DNA methylation and lncRNA regulation remain elusive in lung carcinoma epigenetics. We present an application toolkit MetLnc in integration and annotation for group-wise NSCLC tissue-based DNA methylation and lncRNA profiling resources, to comprehensively analyze differentially methylated loci and lncRNAs through genome-wide analysis. Together with multiple analytic functions, MetLnc acts as an efficient approach on epigenetic omics integration and interrogation. Via the benchmark with group-wise NSCLC tissue profiling and TCGA cohort resources, we study differentially methylated CpG loci and lncRNAs as meaningful clues for inferring crosstalk effects between DNA methylation and lncRNA regulation; together we conclude with investigated biomarkers for further epigenetics and clinical trial research.