Chemical Communications · 2018 · 42 citations · 40 references
MedicineNatural SciencesMedicinal ChemistryOncologyCancer PharmacologyChemotherapySupramolecular ChemistryDrug EncapsulationHost-guest ChemistrySupramolecular MaterialsSupramolecular RecognitionAnticancer ActivityAnticancer ChemotherapyCell InternalizationCellular Internalization PathwaysHost ChemistryPillararene RecognitionSupramolecular ComplexationSupramolecular Encapsulation
Based on the host-guest interaction between a CPT-conjugated prodrug amphiphile (CPT-ss-Py) and a water-soluble pillar[5]arene (P5), a GSH-responsive supramolecular chemotherapeutic drug (P5⊃CPT-ss-Py) was fabricated. Through this supramolecular formulation, internalization and anticancer efficacy were greatly increased.
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Functionalizing Pillar[<i>n</i>]arenes
Nathan L. Strutt, Huacheng Zhang, Severin T. Schneebeli et al. · Accounts of Chemical Research · 2014 · 580 citations
Zhongyu Li, Yanyan Zhang, Changwei Zhang et al. · Journal of the American Chemical Society · 2014 · 537 citations