Angewandte Chemie International Edition · 2018 · 47 citations · 40 references
Natural SciencesBiochemistryChemistryBiocatalysisCatalysisEnzymologyBiocatalytic StereoselectivityCatalytic MechanismsChemoenzymatic SynthesisChiral SeparationEnzymatic CatalysisOrganic SynthesisChemoenzymatic Asymmetric SynthesisChemoenzymatic OxidationEnantioselective BiocatalysisEnantioselective CatalysisEnantioselective OxidationEnantioselective SynthesisMethionine Sulfoxide Reductase SystemOxidant Chemistry
The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine-type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.
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